"System.IO.DirectoryNotFoundException" occurs when attempting to load Reflection Desktop

The following Exception Errors can occur and appear in the Windows Event Viewer when attempting to load the Reflection Workspace:

Application: Attachmate.Emulation.Frame.exe
Framework Version: v4.0.30319
Description: The process was terminated due to an unhandled exception.
Exception Info: System.IO.DirectoryNotFoundException
   at System.IO.__Error.WinIOError(Int32, System.String)
   at System.IO.FileStream.Init(System.String, System.IO.FileMode, System.IO.FileAccess, Int32, Boolean, System.IO.FileShare, Int32, System.IO.FileOptions, SECURITY_ATTRIBUTES, System.String, Boolean, Boolean, Boolean)
   at System.IO.FileStream..ctor(System.String, System.IO.FileMode, System.IO.FileAccess, System.IO.FileShare, Int32)
   at Attachmate.Utilities.TempFileHelper.GetTempFileNameWithExtension(System.String)
   at Attachmate.Emulation.Frame.UIManager.LoadSystemUI(System.String)
   at Attachmate.Emulation.Frame.UIController.InitUiManager(System.String)
   at Attachmate.Emulation.Frame.UIController.LoadSystemUI()
   at Attachmate.Emulation.Frame.FrameApplication.Run()
   at Attachmate.Emulation.Frame.Program.Main()

Faulting application name: Attachmate.Emulation.Frame.exe, version: 17.0.434.0, time stamp: 0x5f9bcad3
Faulting module name: KERNELBASE.dll, version: 6.3.9600.19724, time stamp: 0x5ec50c3e
Exception code: 0xe0434352
Fault offset: 0x000156e8
Faulting process id: 0xa94
Faulting application start time: 0x01d746a7369bd7dc
Faulting application path: C:\Program Files (x86)\Micro Focus\Reflection\Attachmate.Emulation.Frame.exe
Faulting module path: C:\Windows\SYSTEM32\KERNELBASE.dll
Report Id: 776bdc96-b29a-11eb-80e9-000c29e7689b
Faulting package full name:
Faulting package-relative application ID:

The cause of this problem is a missing Windows Temporary file folder.  The Windows Environment Variables for TEMP and TMP need to be set to a valid existing folder location.